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Cancer Genome and Tumor Microenvironment

Release on 2010-01-232010-01-23 by Andrei Thomas-Tikhonenko
Cancer Genome and Tumor Microenvironment

Author: Andrei Thomas-Tikhonenko

Publisher: Springer Science & Business Media

ISBN: 1441907114

Category: Medical

Page: 480

View: 513

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ’80s-early ’90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer has slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc. The commonly held view is that changes in tumor microenvironment are “soft-wired”, i.e., epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these non-cell-autonomous changes might be one of the primary reasons such mutations are preserved in late-stage tumors.
Medical
Cancer Genome and Tumor Microenvironment
Language: en
Pages: 480

Cancer Genome and Tumor Microenvironment

Authors: Andrei Thomas-Tikhonenko
Categories: Medical
Type: BOOK - Published: 2010-01-23 - Publisher: Springer Science & Business Media

Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ’80s-early ’90s, neoplastic growth was described largely as an imbalance between net cell accumulation and loss, brought about through mutations in cancer genes.
The Tumor Microenvironment: Recent Advances and Novel Therapeutic Approaches
Language: en
Pages: 157

The Tumor Microenvironment: Recent Advances and Novel Therapeutic Approaches

Authors: Sandra Orsulic, Hasan Korkaya
Categories: Science
Type: BOOK - Published: 2021-12-03 - Publisher: Frontiers Media SA

Books about The Tumor Microenvironment: Recent Advances and Novel Therapeutic Approaches
Exploring the breast tumor microenvironment: Association to metastasis, novel risk factors and novel treatments and immunotherapies
Language: en
Pages: 398

Exploring the breast tumor microenvironment: Association to metastasis, novel risk factors and novel treatments and immunotherapies

Authors: Jorge Morales-Montor, Karen Elizabeth Nava-Castro, Mariana Segovia
Categories: Medical
Type: BOOK - Published: 2023-01-10 - Publisher: Frontiers Media SA

Books about Exploring the breast tumor microenvironment: Association to metastasis, novel risk factors and novel treatments and immunotherapies
Manipulating the Immunological Tumor Microenvironment
Language: en
Pages: 792

Manipulating the Immunological Tumor Microenvironment

Authors: Peng Qu, Huanfa Yi, Keqiang Chen
Categories: Medical
Type: BOOK - Published: 2022-03-31 - Publisher: Frontiers Media SA

Books about Manipulating the Immunological Tumor Microenvironment
Using Germline Variation to Study Inter-Individual Variability in Cancer Risk and Host Anti-Tumor Immune Response
Language: en
Pages: 0

Using Germline Variation to Study Inter-Individual Variability in Cancer Risk and Host Anti-Tumor Immune Response

Authors: Meghana Pagadala
Categories: Medical
Type: BOOK - Published: 2022 - Publisher:

Cancer is a complex disease driven by genetic variation(1-3). Two main types of genetic variation include germline variation, which is inherited, and somatic variation, which is acquired through environmental exposures and endogenous processes, such as DNA replication. Both types of genetic variation have been critical for precision medicine, tailored to

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