Chemical derivatisation of functional groups has proved popular since the beginning of organic mass spectrometry as a means to enhance the stability and volatility of the analytes as well as facilitating structure elucidation. This book provides comprehensive information on the wide range of derivatisation methods. Each chapter looks at a particular area of derivatisation and includes extensive references to the literature for further research where necessary. There are nearly 1800 references, which, as well as full bibliographic information, include chapter/paper titles where appropriate and Digital Object Identifiers (DOIs) to allow easy retrieval of the online version of the referenced publication. The emergence of atmospheric pressure ionisation and other soft ionisation techniques has not diminished the interest in such chemical techniques, as witnessed by the many chemical tags used in quantitative proteomics (Chapter 9). The last two chapters, a substantial part of the book, deal with derivatisation for use with soft ionisation of both small and large molecules. Chapters Silylation Acylation Alkylation (Arylation) Cyclic derivatives Monofunctional compounds Polyfunctional compounds On-line derivatisation/degradation Soft ionisation—small molecules Soft ionisation—large molecules
Type: BOOK - Published: 2009 - Publisher: IM Publications
Chemical derivatisation of functional groups has proved popular since the beginning of organic mass spectrometry as a means to enhance the stability and volatility of the analytes as well as facilitating structure elucidation. This book provides comprehensive information on the wide range of derivatisation methods. Each chapter looks at a
Type: BOOK - Published: 1994-01-25 - Publisher: CRC Press
Describes general aspects of metals in clinical chemistry focusing not only on the physiology of metal ions and their analytical determination in biological materials, but also on their geochemical distribution, technical uses and environmental effects.
Type: BOOK - Published: 2017-11-22 - Publisher: CRC Press
Adapting modern advances in analytical techniques to daily laboratory practices challenges many toxicologists, clinical laboratories, and pharmaceutical scientists. The Handbook of Analytical Therapeutic Drug Monitoring and Toxicology helps you keep abreast of the innovative changes that can make your laboratory - and the studies undertaken in it - a success.
Type: BOOK - Published: 2021-11-23 - Publisher: Royal Society of Chemistry
This book gathers, in a single resource, knowledge about matrix-assisted laser desorption ionisation (MALDI) mass spectrometry imaging. It includes fundamentals in the MALDI ionisation process, different source geometries and capabilities, detection systems and the latest research and applications in the range of –omics area as well as other broader areas.
Type: BOOK - Published: 2013-09-03 - Publisher: Springer-Verlag
Wenn ich das hier nunmehr in zweiter Auflage erscheinende Werk: "Radio aktive Isotope in Physiologie, Diagnostik und Therapie" durchblättere, dann überkommt mich ein Staunen, fast auch eine gewisse Bedrückung. Ich sehe, was aus einem noch vor 50 Jahren in den Kinderschuhen steckenden Wissenschafts gebiet heute geworden ist. Als ich mich