Type: BOOK - Published: 2016-07-29 - Publisher: OECD Publishing
This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.
Authors: Jan Willem van der Laan, Joseph J DeGeorge
Type: BOOK - Published: 2013-02-11 - Publisher: Springer Science & Business Media
This volume will consider one of ICH’s major categories, Safety i.e. topics relating to in vitro and in vivo pre-clinical studies (Carcinogenicity Testing, Genotoxicity Testing, etc.). Since the start of the ICH process, many guidelines have been written, but even after ICH6 no explanations have been given during a formal
Type: BOOK - Published: 2016-06-28 - Publisher: Dorrance Publishing
The Vindication of Lewis M. Roach By Tara Hime Norman One cold December night in 1913a quiet rural community was rocked by the brutal murder of an elderly farmer. The case was solved, but there was one other victim: the innocent man who was executed.
Authors: Raymond D. Harbison, Marie M. Bourgeois, Giffe T. Johnson
Type: BOOK - Published: 2015-04-13 - Publisher: John Wiley & Sons
Providing a concise, yet comprehensive, reference on all aspects of industrial exposures and toxicants; this book aids toxicologists, industrial hygienists, and occupational physicians to investigate workplace health problems. • Updates and expands coverage with new chapters covering regulatory toxicology, toxicity testing, physical hazards, high production volume (HPV) chemicals, and workplace