Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Type: BOOK - Published: 2014-02-25 - Publisher: CRC Press
Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along
Type: BOOK - Published: 2015-04-10 - Publisher: Springer
Basic research on the pharmacology of itch has exploded in the wake of two very influential papers that were published in Nature (2007) and Science (2009). Long overlooked as a milder form of pain, itching has rapidly gained a new appreciation in both research and clinical communities because of its
Authors: Gil Yosipovitch, Malcolm W. Greaves, Jr., Alan B. Fleischer, Francis McGlone
Categories: Medical
Type: BOOK - Published: 2004-01-06 - Publisher: CRC Press
Offering details on the pharmacology of itch, techniques of itch evaluation, and neurogenic itch, this reference presents new concepts in the neurophysiology and central mechanisms of itch, animal models of itch, and processing of histamine itch in the human cerebral cortex. The text clarifies itch in systemic and skin disease,
Authors: Sakari Reitamo, Thomas A. Luger, Martin Steinhoff
Categories: Medical
Type: BOOK - Published: 2008-05-01 - Publisher: CRC Press
Atopic dermatitis or atopic eczema is an extremely common skin disease characterized by red patches, dry, scaling or crusting skin, and intense itch. It frequently develops in children during the first year of life and can become severe, with a consequently major impact on health-related quality of life. This text