Protein Kinase C in Cancer Signaling and Therapy

Release on by Marcelo G. Kazanietz
Protein Kinase C in Cancer Signaling and Therapy

Author: Marcelo G. Kazanietz

Publisher: Springer Science & Business Media

ISBN: 9781607615439

Category: Medical

Page: 494

View: 264

Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due to early studies in the mouse skin carcinogenesis model, which showed that prolonged topical application of phorbol esters promoted the formation of skin tumors on mice previously treated with mutagenic agents. Research in the last years has established key roles for PKC isozymes in the control of cell proliferation, migration, adhesion, and malignant transformation. In addition, there is a large body of evidence linking PKC to invasion and cancer cell metastasis. Moreover, it is now well established that the expression of PKC isozymes is altered in various types of cancers. More importantly, small molecule inhibitors have been developed with significant anti-cancer activity. The relevance of PKC isozymes in cancer signaling is therefore remarkable. This book will have 4 sections. There will be 23 chapters. Each section will have a brief introduction by an expert in the field (~ 1-2 pages).
Medical
Protein Kinase C in Cancer Signaling and Therapy
Language: en
Pages: 494

Protein Kinase C in Cancer Signaling and Therapy

Authors: Marcelo G. Kazanietz
Categories: Medical
Type: BOOK - Published: 2010-06-10 - Publisher: Springer Science & Business Media

Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due
Protein Kinase C in Cancer Signaling and Therapy
Language: en
Pages: 494

Protein Kinase C in Cancer Signaling and Therapy

Authors: Marcelo G. Kazanietz
Categories: Medical
Type: BOOK - Published: 2011-07-21 - Publisher: Humana Press

Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer research field due
Regulation of immune system cell functions by protein kinase C
Language: en
Pages: 129

Regulation of immune system cell functions by protein kinase C

Authors: Noah Isakov, Amnon Altman
Categories: Immunologic diseases. Allergy
Type: BOOK - Published: 2014-11-11 - Publisher: Frontiers E-books

Members of the protein kinase C (PKC) family of Ser/Thr kinases are encoded by nine distinct but closely related genes, which give rise to more than 12 different protein isoforms via a mechanism of alternative RNA splicing. Most PKC proteins are ubiquitously expressed and participate in a plethora of functions
Polyphenols-based Nanotherapeutics for Cancer Management
Language: en
Pages:

Polyphenols-based Nanotherapeutics for Cancer Management

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Categories: Immunologic diseases. Allergy
Type: BOOK - Published: - Publisher: Springer Nature

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Protein Kinase C
Language: en
Pages:

Protein Kinase C

Authors: Dean J. Pierce
Categories: Immunologic diseases. Allergy
Type: BOOK - Published: 2018 - Publisher:

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